Conceptual Process Design Course & PROSYN® workshop – 2019

Conceptual Process Design Course & PROSYN® workshop – 2019

June 4th /5th , 2019 – Breda (NL)

Following the successful and well attended previous event, we will again organize our Conceptual Process Design Course and PROSYN® Workshop in June of this year.


Developing or improving process concepts of a petrochemical or biochemical plant is a challenging and important task. After all, the Conceptual Process Design (CPD) has a crucial impact on the final plant design and cost.
Process Design Center has proven that by application of structured CPD tools and methods it is possible to realize cost and energy savings up to 50%! It is thus important to maximize the impact of your CPD efforts, especially in an early stage of R&D.

The Conceptual Process Design Course introduces structured CPD methods and covers the essential elements needed to develop a first process design. At the end of the course participants will be familiar with these aspects, which include the development of a flowsheet, selection and design of reaction- and separation technologies, equipment and process intensification, and  generation of an equipment factored (class 4) cost estimate. The course includes several examples of practical cases from the (bio-) chemical industry.

The PROSYN® workshop allows to familiarize yourself with artificial intelligence tools for conceptual design by working with PROSYN® on a design problem of your own choice. The conceptual design case may be taken from your daily practice, but it is also possible to run specific examples which are available at the workshop.


The course is intended for professionals working in an R&D or chemical engineering environment in the industry, RTOs and academia. Participants should have a basic understanding of chemical engineering.


This course will be organized at the office building of PDC/Keuken & de Koning, Catharinastraat 21f, 4811 XD Breda, The Netherlands. The building is located in the picturesque historic city center of Breda. From Schiphol Airport it takes 50 minutes by high-speed train (Intercity Direct) and from Brussels Airport 1 hour and 10 minutes to reach Breda central station, which is at walking distance from the course location.


The course is structured as a two-day event, which is scheduled from Tuesday,  June 4 th , 9:00 (CET) until Wednesday, June 5 th , 15:30 (CET).

DAY 1 – June 4th , 2019
  • Introduction
    • Importance and benefits
    • Real-life examples from CPD projects
  • Structured methods
    • Design principles and approaches used in CPD
    • Alternative methods (decomposition, branch and bound, evolutionary, hierarchical,
      superstructure optimization, heuristic-numeric) are introduced and compared
  • Mass & energy balancing
    • Setting up mass balances with inclusion of reaction and separation blocks and recycles
    • Various techniques to solve mass balances
    • Case studies to use mass balances as a tool for decision making in CPD
  • Basic data and physical properties
    • Introduction to physical properties, phase equilibria, and physical property models
    • Implications of non-ideal behavior in process design
    • Data sources, data validation, and regression
    • Examples of non-ideal mixtures and model artefacts
12:30 – 13:30 LUNCH
  • Reactor selection and design
    • Reaction equilibria and reaction kinetics
    • Using reactor design to control reactions: Reactant addition, product removal,
      backmixing characteristics, temperature, pressure, contacting of phases, catalyst
      structure, etc.
    • Technical reactor concepts
    • Design of reactors as part of a process
14:30 – 17:30 PROSYN® WORKSHOP (PART 1)
In the workshop you are invited to bring the course knowledge into practice by operating PROSYN® yourself on a case or example of your interest. If you select your own case, we recommend limiting it to a specific conceptual design problem in view of the available time. For example you may wish to
investigate the reactor selection and design for specific chemistry or investigate a separation problem.
To ensure the highest effectiveness, we recommend informing us in advance of the case you would like to investigate with PROSYN®.
A course dinner is organized in the historic city center of Breda, an inspiring place for an informal dinner with the other course participants and conceptual design experts.
DAY 2 – June 5th , 2019
  • Separation technologies
    • Phase separation by distillation (simple, azeotropic, extractive) or crystallization
    • Affinity separation (extraction, absorption, adsorption, chromatography, SMB)
    • Membrane separation
    • Separations and recycles
  • Equipment and process intensification
    • Equipment intensification of separators, reactors, heat exchangers and other equipment
    • Reactive separations with a focus on reactive distillation. Example on production of methyl-acetate using reactive distillation
  • Process economics
    • Classification of cost estimates
    • Equipment cost correlations and installation factors
    • CAPEX and OPEX estimation
  • Heat integration in conceptual design
    • Introduction to pinch analysis
    • Exploiting pressure effects and using superheated steam dryers, multi-effect evaporators, and mechanical vapor recompression to reduce energy use
  • Final remarks and wrap-up
12:00 – 13:00 LUNCH
13:00 – 15:00 PROSYN® WORKSHOP (PART 2)
Continuation of the PROSYN® workshop.


The fee for the course and workshop is € 1500 per participant (excl. VAT). Course material, coffee/tea, lunch, and the dinner on Tuesday evening are included in the fee.


The language used during the course and workshop is English. For the workshop, participants are requested to bring a computer or laptop which allows internet access. This is needed to connect to the PROSYN® server. In case of doubts, please contact us to check the system requirements.

Hotel suggestions:

  • Apollo Hotel Breda City Centre (
  • Hotel Nassau Breda (

Both hotels are located at a convenient walking distance from the course location. A reduced rate applies for the course participants, which is not included in the fee.


Dr. Hank Vleeming joined PDC/Keuken & de Koning 20 years ago and is Chief Technology Officer (CTO). He holds a Master Degree in Chemistry from Leiden State University (1992) and a PhD degree in chemical engineering from the Eindhoven University of Technology (1997). His expertise is in conceptual
process design using expert systems. He gained broad technology and industrial experience working with clients and partners in Europe, Asia, and North & South America.

Dr. ir. Raf Roelant has over eight years of experience as Chemical Engineer and Consultant at PDC/Keuken & de Koning. He holds a Master and PhD Degree in Chemical Engineering from Ghent University. He has worked mainly on processes converting biomass to chemicals and fuels through catalytic reactions and fermentation. His specialty is reaction engineering.


You can register for the course by sending an email before May 22nd , 2019 citing ‘Conceptual Process Design Course and Workshop 2019’, and including your name, email address, phone number, company/organization, invoice address and VAT number. After registration you will receive a confirmation, an invoice, route description, and further information related to parking and  hotels nearby.

The number of participants is limited to 15 so early registration is recommended. Cancellation with a full refund is possible up to 2 weeks before the start of the course. After this date restitution of the course fee is no longer possible. Substitutions are possible at all times.


For further information and registration, please contact:

PDC/Keuken & de Koning
Ms. Marianne Niemantsverdriet
Phone: +31 (0)76 – 530 19 00

Process Design Center / Keuken & de Koning training course information.
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